Solid self‑emulsifying pellets: Solubility enhancement for oral delivery of poorly soluble BCS Class II drug

The review focused on technique of solid self-emulsifying pellets (SEPs) for solubility enhancement poorly water soluble drug. oral route administration has been and still is currently the primary drug delivery owing to its potential advantages compared other routes. process hydrophobic drugs plays a key role in formulation development achieve bioavailability therapeutic action at target site.1 Around 40% probe new are characterized as belonging class II BCS classification (poorly highly permeable), giving rise poor erratic bioavailability. SEPs system combines liquid Self emulsifying with those dosage form, which can overcome limitations formulations improve storage stability patient compliance. To enhance dissolution absorption insoluble selfmicroemulsifying develop evaluated. showed significant quicker redispersion rate than commercial tablets. might be an encouraging strategy Poorly extrusion–spheronization method feasible technology solidification SMEPs. microemulsifying effective pharmaceutical widely used during recent years have some successful products market (e.g. Neoral®, Norvir® Fortovase®).
 Keywords: Emulsifying Pellets, Bioavailability, Solubility, extrusion–spheronization, Biopharmaceutical Classification.